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Appendix - IV 205
6. Fill the bottle with purified water and close it with the stopper. (Some water will come out from the bottle. Wipe out with the help of a clean cloth or tissue paper. )
7. Weigh the bottle along with water.
8. The weight is noted as W2 .
9. Pour out the water, and rinse the bottle with the liquid whose density to be determined.
10. Fill the density bottle with the liquid. Close it with the stopper.
11. Weight of the bottle along with the liquid is noted as W3 .
12. Repeat the experiment 2�3 times and take the average values for calculation.
OBSERVATION AND CALCULATIONS
Table 4.2: Determination of Density
Weight of the empty bottle
Weight of the bottle +water
(W 2) g
Weight of bottle +liquid
Density of the liquid at t °C
Weight of empty bottle with stopper
Weight of bottle +water
Weight of bottle +liquid
Weight of water in the density bottle
Weight of liquid in the density bottle
Density of the liquid =
W2 � W1 = ���.gSee All Chapters
182 A Practical Manual of Pharmaceutical Engineering
EVALUATION OF MATERIALS USED
IN PHARMACEUTICAL PACKAGING—
To evaluate the given packaging material (Corrugated board).
(Cut in to pieces of 5 inch ¥ 4 inch)
Fractional weight box
Corrugated board can be defined as the structure formed by gluing one or more fluted corrugated medium to one or more flat facings of liner board. It has been used as a packaging material for more than 100 years and still maintains a healthy share in the market despite increasing competition from plastics. The major advantages of the corrugated boards are:
1. High stiffness to weight ratio
2. Reasonable shock resistance and cushioning properties
3. Fully biodegradable and recyclable
4. It is versatile and can be used for various packaging requirements of different industries
Corrugated board usually consists of two basic components. Line board and corrugating medium.See All Chapters
186 A Practical Manual of Pharmaceutical Engineering
(in the form of sand) with two or other materials, e.g., soda ash and lime stone at very high temperatures. Glass containers for pharmaceutical use are intended to come in to direct contact with pharmaceutical preparations. Glass used for pharmaceutical containers is either a borosilicate glass or a soda lime glass. Borosilicate glass contains boric oxide, aluminum oxide, and alkali and/or alkaline earth oxides. It has a high hydraulic resistance. They are classified as Type 1 glass. On the other hand soda lime glass contains alkali metal oxides and considered to have a moderate hydraulic resistance. This will comes under Type 3 glass. If the soda lime glass is treated to improve the hydrolytic resistance they are categorized under Type 2 glasses. The quality of the glass containers is dependent on their resistance to chemical attack.
One of the major problems with the glass container is the alkali extraction when aqueous preparations are stored for a fairly long period. This may cause the increase in the pH of the solution.See All Chapters